Semaglutide
The most studied weight-loss drug available. Sold as Wegovy and Ozempic, as a weekly injection or a daily pill. Large trials behind it and a known side-effect profile.
Find a compound
Pick what you are trying to do. Every result shows its evidence grade and whether there is a lawful way to get it, because those two things matter more than the marketing.
Tirzepatide
Acts on two hormone receptors instead of one. Sold as Zepbound and Mounjaro. Produced some of the largest weight reductions seen in obesity trials.
Tesamorelin
The only growth-hormone-type drug with a current FDA approval. Narrowly approved to reduce excess abdominal fat in people with HIV and lipodystrophy; the fat returns if you stop.
Retatrutide
Eli Lilly's experimental triple-hormone injection, with strong Phase 3 results and a planned FDA filing. Available only through clinical trials right now.
Mazdutide
A weekly weight-loss injection approved in China in 2025. Real approval, real trials, but no route to it in the United States.
AOD-9604
Tested properly and failed. Its 536-person trial found no significant weight loss against placebo. Safety record was clean; the drug simply did not work.
5-amino-1MQ
Not a peptide. Blocks an enzyme involved in NAD+ metabolism. Striking results in obese mice, zero published human trials, and a 40-fold spread in the doses people inject.
SLU-PP-332
The "exercise pill." Mice ran 70% longer and obese mice lost weight. No human has been given it in a registered trial.
Adipotide
Destroys the blood vessels feeding fat tissue. Produced about 11% weight loss in monkeys and damaged the kidneys of every treated animal at the same doses.
Growth hormone (HGH)
The real thing, approved for deficiency and specific medical conditions. Federal law bars distributing it for anti-aging or bodybuilding, which is most of what it is sought for.
Sermorelin
Signals your pituitary to release its own growth hormone rather than supplying hormone directly. Prescribed and compounded legally, with modest evidence for the uses it is marketed for.
Ipamorelin
The most popular growth hormone secretagogue, usually sold with CJC-1295. Raises growth hormone reliably. Its only human trial, in post-surgical recovery, failed.
CJC-1295
Keeps growth hormone elevated for days after one injection. The entire human record is a 2006 Phase 1 study that measured hormone levels, not results.
GHRP-2 and GHRP-6
Older growth hormone releasers. They work, and they also raise cortisol, prolactin and appetite, which is why clinicians moved on from them.
IGF-1 LR3
A laboratory reagent sold for muscle growth. No human trials at all. The approved IGF-1 drug carries warnings for severe low blood sugar and for malignancy.
BPC-157
The best-known repair peptide, now legally compoundable. Almost all of its evidence is animal work, and an investigation found most of it came from a single lab.
TB-500
Related to thymosin beta-4 and usually paired with BPC-157. Legally compoundable since October 2026; human evidence for healing is essentially absent.
KPV
A three-amino-acid peptide taken orally or applied to skin, marketed for gut and skin inflammation. Covered by the 2026 policy, with thin human data.
GHK-Cu and the Glow stack
A copper peptide with genuine evidence in skincare, where it is sold as a cosmetic. The injectable version is a different proposition and awaits FDA review.
Melanotan II
Darkens skin and raises libido. Also associated with changes to moles and reports of melanoma. No legal route; FDA review due February 2027.
Semax
A nasal peptide from Russian research, now legally compoundable as a nasal spray. Marketed for focus and recovery after stroke.
Selank
Approved in Russia as an anti-anxiety nasal spray, with small trials suggesting benzodiazepine-like effect without sedation. No Western trials and no US route.
Dihexa
Sold for memory. No human data of any kind, and the paper describing how it was supposed to work has been retracted.
Methylene blue
An approved prescription drug for one rare blood condition, now sold in dropper bottles for focus. Carries a boxed warning for serotonin syndrome with SSRIs and similar drugs.
DSIP
A sleep peptide from the 1970s. In July 2026 it was the only one of seven compounds an FDA advisory committee voted against allowing pharmacies to compound.
Epitalon
A four-amino-acid peptide sold for longevity and telomere effects. Legally compoundable in courses since October 2026; the human evidence is old and limited.
MOTS-c
Encoded in mitochondrial DNA and marketed for metabolism and energy. Newly compoundable, with the human evidence still to come.
NAD+
A coenzyme central to cell metabolism. Oral precursors have human trials behind them; the injected and IV versions sold by clinics largely do not.
HCG
Imitates the body's signal to ovulate or to produce testosterone. Approved for fertility and certain cases of low testosterone. Not approved for weight loss, despite the diet industry built on it.
Kisspeptin
The hormone that starts puberty. Has real controlled trials in IVF and in low sexual desire, though the version sold online differs from the one studied.
How to read the grades. The grade describes how much is known about a compound in human beings, not how well it is claimed to work. A compound can carry a D because nobody has studied it properly, and an A because it was studied properly and the answer was unflattering. Legal status is a separate question again, shown on its own tag.
The grades, decoded
| Grade | What it means | Count |
|---|---|---|
| A | Large, well-run human trials Several good studies in people, with results that hold up. You can plan around what these do, including the side effects. | 6 |
| B | Real human trials, but limited Tested in people, but the studies are small, early, run outside the US, or the result was negative. Promising or disproven, not settled. | 5 |
| C | Some human evidence, thin A few human studies, usually small, old, unreplicated, or measuring the wrong thing. Most of the marketing outruns what was actually shown. | 10 |
| D | Animals and laboratories only No useful human data. Everything claimed comes from mice, cells, or forum reports. Nobody knows what a safe or effective dose in a person is. | 9 |
Two things the grade does not tell you. It is not a safety rating: Melanotan II carries a C and has melanoma reports against it, while a D compound may simply be untested. And it is not legal advice: several B and C compounds have no lawful route in the US at all.
Looking for a blend rather than a single compound? Wolverine, Glow and KLOW are covered on the blends and stacks page.