Kisspeptin
Kisspeptin is a natural hormone that sits at the top of the reproductive axis. It has better controlled-trial evidence than most compounds in this library. The catch is that the form sold online is not the form most of those trials used.
- Legal lane: investigational. No FDA-approved product.
- Evidence grade: B
- Form: injection; trials used intravenous and subcutaneous routes
- Two versions: kisspeptin-10 (commonly sold) and kisspeptin-54 (used in the strongest trials)
What it is
Kisspeptin signals the hypothalamus to release GnRH, which in turn drives LH and FSH and the sex hormones downstream. It is the switch that starts puberty.
Kisspeptin-10 is a short fragment with a half-life measured in minutes. Kisspeptin-54 is longer-acting and is what researchers used in the trials below. Vendors usually sell the -10 form; do not read trial results from one as evidence for the other.
What the evidence shows
- Fertility: teams at Imperial College London used kisspeptin as the trigger for egg maturation in IVF, reporting effective maturation with a lower risk of ovarian hyperstimulation syndrome than the standard trigger.
- Sexual desire: two randomized placebo-controlled trials published in JAMA Network Open, one in men and one in 32 premenopausal women with low sexual desire, reported changes in brain activity and in some behavioral measures.
- These are small, early-phase studies in clinical settings, not evidence for general use.
Legal status
Kisspeptin remains investigational. There is no approved product, and it was not included among the peptides opened to compounding in 2026. Material sold online is a research chemical.
Dosing in studies
No approved dose exists.
Trials dosed by body weight, intravenously or by infusion, under direct supervision, using kisspeptin-54 in most cases. The round numbers circulating in forums for the -10 form do not come from any of this work.
Safety
- Trial participants tolerated it well over short exposures under supervision.
- Nothing is known about repeated self-administration over months.
- It acts on the hormonal axis that controls reproduction, so effects on fertility, cycles and testosterone are plausible and unstudied outside the trial settings above.